Prof. Maria Moreira
The most frequent health problem in the world is the loss of dental pulp vitality due to trauma or infectious diseases. This leads to the need for root canal treatment, which results in non-vital teeth with impairment of functions of these organs. In immature teeth the scenario is worst, the root development is compromised leading to root fracture and tooth loss. To circumvent this problem researchers are looking for strategies of regeneration of the lost dental pulp tissue by applying either cell therapy or tissue engineering. The use of endogenous cells recruited from the blood as well as the periapical tissues would be easier accepted by both clinicians and patients. In fact, the active recruitment of endogenous stem cells into dental root canals to regenerate pulp-like tissues is a new concept that may offer an extraordinary opportunity for the near-term clinical translation of current biology-based therapies for dental pulp regeneration. Additionally Photobiomodulation can increase cell metabolism, leading to improvements in the survival, proliferation, migration, and differentiation of the stem cells and showed the ability to activate endogenous morphogen, which are processes of relevance for tissue regeneration.
This lecture will provide information regarding biological bases for dental pulp regeneration and photobiomodulation and review the endodontics regenerative procedures. Benefits and limitations of apical revascularization are critically reviewed and will be pointed out, future perspectives will be given, where application of the principles of tissue engineering with the use of scaffolds, growth factors and photobiomodulation might optimize cell homing strategy for dental pulp regeneration in immature and mature teeth.
To present data from clinical, in vitro-experiments and animal studies. To provide background information on the biological bases of photobiomodulation and regenerative endodontic procedures.